Can Nootropics Help with Anxiety or Depression?

Nootropics, also known as "smart drugs" or cognitive enhancers, have gained popularity in recent years for their potential to improve cognitive function, memory, and focus. But can they also help with anxiety or depression? In this article, we'll delve into the world of nootropics and explore what the scientific community has to say about their potential for alleviating these common mental health issues. We'll then tell you what we think are the best nootropics for anxiety (including panic attacks and social anxiety) you can take today.

Nootropics: An Overview

Nootropics are substances that can enhance cognitive function, with minimal side effects. They can be found in various forms, including natural compounds, synthetic drugs, and even certain foods. Some popular nootropics include caffeine, L-theanine, and racetams (like piracetam).

Anxiety and Depression: The Connection

Anxiety and depression are two of the most common mental health disorders, affecting millions of people worldwide. They often co-occur, and both can have a significant impact on daily life. While the exact causes of anxiety and depression are complex and multifaceted, research has linked these conditions to imbalances in neurotransmitters, such as serotonin, dopamine, and norepinephrine.

Nootropics for Anxiety

Several nootropics have been researched for their potential to help with anxiety. Here are a few noteworthy examples:


L-theanine is an amino acid found naturally in green tea. It has been shown to have a calming effect on the brain by increasing levels of the neurotransmitters GABA and serotonin, which are involved in relaxation and mood regulation. A 2019 review of studies found that L-theanine was effective in reducing anxiety symptoms in individuals with high levels of anxiety.


Aniracetam is a synthetic nootropic that belongs to the racetam family. It has been shown to have anxiolytic (anti-anxiety) effects, possibly due to its ability to modulate the release of neurotransmitters like dopamine and serotonin. A 2001 study found that aniracetam reduced anxiety-related behaviors in rats.

Rhodiola Rosea

Rhodiola rosea is an adaptogenic herb that has been used traditionally to help the body cope with stress. Some studies suggest that it may help to reduce anxiety symptoms by balancing stress hormones and improving neurotransmitter function. A 2015 review of clinical trials found that Rhodiola rosea had a significant anti-anxiety effect in some populations, particularly those with mild to moderate anxiety.

Nootropics for Depression

Several nootropics have also been researched for their potential to help with depression. Some of these include:

S-Adenosyl Methionine (SAMe)

SAMe is a naturally occurring compound in the body that plays a crucial role in various biochemical reactions. It has been found to have antidepressant effects by increasing the availability of neurotransmitters like serotonin and dopamine. A 2016 meta-analysis concluded that SAMe was more effective than a placebo in reducing depressive symptoms.


Ginseng is a widely-used adaptogenic herb that has been traditionally used in Chinese medicine for centuries. It is known for its potential to enhance physical and mental performance, as well as providing stress-relief and balancing the body's systems. Studies have shown that ginseng may have potential antidepressant effects, which could make it beneficial for those dealing with depression.

In a 2013 review of studies on ginseng, researchers found evidence suggesting that ginseng has neuroprotective, anti-inflammatory, and antioxidant properties. These properties could potentially help alleviate depressive symptoms by regulating neurotransmitter systems and reducing inflammation in the brain.


Tyrosine, an amino acid found in protein-rich foods, can also serve as a potential nootropic for depression. It plays a critical role in the production of dopamine, a neurotransmitter involved in mood regulation and motivation. A study published in 2013 demonstrated that supplementing with L-tyrosine could increase dopamine levels in the brain, which might help alleviate depressive symptoms. By providing the necessary building blocks for dopamine production, tyrosine supplementation could potentially improve mood and overall cognitive function in individuals struggling with depression. However, it is essential to note that more research is needed to confirm these findings and establish the optimal dosage for this purpose.

Nootropics vs. Anti-Depressants

When discussing the potential benefits of nootropics for anxiety and depression, it's essential to consider how they compare to conventional anti-depressants. While nootropics are typically seen as cognitive enhancers that improve memory, focus, and learning, some of them have also shown potential in addressing mood disorders.

Anti-depressants, on the other hand, are specifically designed to treat depression and anxiety disorders by targeting neurotransmitter imbalances in the brain. They usually fall into categories like selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs), among others. These medications have a long history of clinical use and are typically prescribed by healthcare professionals.

One key difference between nootropics and anti-depressants is the mechanism of action. While anti-depressants primarily focus on increasing the availability of specific neurotransmitters, nootropics often work through a variety of mechanisms, including neuroprotection, anti-inflammation, and improved blood flow to the brain. This broader range of actions could potentially make nootropics more versatile in addressing different aspects of mental health.

Another important distinction is that nootropics generally have fewer side effects compared to anti-depressants, which can sometimes cause drowsiness, weight gain, addiction and dependence, and sexual dysfunction. However, the research on nootropics is still emerging, and they may not be as effective as anti-depressants for severe cases of depression or anxiety.

In conclusion, nootropics and anti-depressants each have their unique benefits and drawbacks. While nootropics may offer a more natural, side effect-free alternative for mild to moderate cases of anxiety and depression, anti-depressants remain the go-to treatment option for more severe cases, supported by extensive clinical research and medical supervision. Individuals seeking help for mental health issues should consult with a healthcare professional to determine the most suitable treatment plan for their specific needs.

Can Nootropics Help with Depression and Anxiety?

In summary, there is promising evidence suggesting that certain nootropics, such as L-theanine, aniracetam, rhodiola rosea, ginseng, and tyrosine, can help alleviate symptoms of anxiety and depression. These natural and synthetic compounds offer a potentially more versatile approach to mental health, with fewer side effects compared to traditional anti-depressants. 

However, it's essential to keep in mind that research on nootropics is still ongoing, and their effectiveness may vary from person to person. If you're considering using nootropics for anxiety or depression, it's crucial to consult with a healthcare professional to develop a personalized treatment plan tailored to your unique needs.