Citicoline vs Alpha-GPC: Differences, Similarities, Which Is better?

by SAP Nutrition April 14, 2023

Citicoline and Alpha-GPC are two popular nootropic supplements known for their efficacy as powerful cognitive enhancers. Both supplements have been shown to improve cognitive function, memory, and focus. But which is the better supplement? In this article, we will compare Citicoline and Alpha-GPC, highlighting their similarities and differences.

What is Citicoline?

Citicoline, also known as CDP-choline, is a naturally occurring choline compound found in the brain. It is an essential nutrient that plays a vital role in acetylcholine synthesis, which is a neurotransmitter responsible for memory and cognitive function. Citicoline is available as a dietary supplement and has been shown to improve cognitive function, brain function, and memory. Several studies have shown that Citicoline can improve attention, mental energy, and executive function in healthy adults, making it a popular nootropic supplement.

What is Alpha-GPC?

Alpha-GPC, or L-alpha-glycerylphosphorylcholine, is a choline supplement that is found in small amounts in dairy products and organ meats. It is also available as a dietary supplement and has been shown to improve cognitive function, memory, and focus. Alpha-GPC is a precursor to acetylcholine synthesis, which is a neurotransmitter responsible for memory and cognitive function. Several studies have shown that Alpha-GPC can improve cognitive function and memory in healthy adults, making it a popular nootropic supplement.

Why Take Choline Supplements (Cholinergics)?

Choline is an essential nutrient that is important for maintaining optimal brain function. It is a source of acetylcholine, a neurotransmitter that plays a key role in memory formation and cognitive performance. Unfortunately, many people do not get enough choline in their diets, which can lead to a variety of cognitive and health problems.

Choline supplements, also known as cholinergics, are a popular way to increase choline intake and support brain health. Here are some reasons why you might consider taking a choline supplement:

To support the production of acetylcholine: Acetylcholine is critical for memory formation and cognitive performance. Choline is a necessary precursor for the production of acetylcholine, so taking a choline supplement can help support healthy levels of this neurotransmitter.
To improve cognitive function: Research has shown that choline supplementation can improve cognitive function and memory in healthy adults and those with cognitive decline [Cohen et al., 1995].
To protect against age-related cognitive decline: As we age, our brains naturally undergo changes that can lead to cognitive decline. Choline supplementation may help protect against this decline by supporting healthy brain function and preventing memory loss [Poly et al., 2011].
To support overall brain health: Choline is important for the formation of cell membranes, which are essential for healthy brain function. It also plays a role in the metabolism of fats and cholesterol, which can impact brain health [Zeisel et al., 2009].
To combat brain fog: Choline can help combat brain fog, a common symptom of fatigue, stress, and poor sleep. By supporting healthy brain function, choline supplementation may help improve mental clarity and focus.

There are many dietary sources of choline, including eggs, liver, and peanuts. However, many people do not consume enough choline through their diets alone. Choline supplements offer a convenient and effective way to support optimal choline intake and maintain brain health.

Alpha-GPC vs Citicoline: Benefits

Alpha-GPC and Citicoline are both cholinergic nootropics that are believed to enhance cognitive performance, memory function, and energy levels. Here are the benefits of each nootropic:

Alpha-GPC:

Increases choline levels in the brain more effectively than other choline supplements due to its higher choline by weight ratio.
Helps with mental performance and memory function, especially spatial memory.
Promotes the synthesis of acetylcholine, an important neurotransmitter involved in learning and memory.
May reduce the risk of neurodegenerative diseases like Alzheimer's disease by increasing neurotrophic factors and improving cellular function.
May improve recovery from ischemic stroke and cerebrovascular diseases.

Citicoline:

Can easily cross the blood-brain barrier and increase choline levels in the brain.
Has more beneficial effects than other cholinergic nootropics due to its other neuroprotective and neuroregenerative properties.
Helps with mental performance, memory function, and energy levels.
May reduce the risk of neurodegenerative diseases by protecting against cellular damage.
May improve recovery from acute stroke and cerebrovascular diseases by promoting cellular repair.

Citicoline is most known for its immediate, short-term benefits. However, the benefits of Citicoline are longer-lasting when the compound is taken daily for long periods of time.

Alpha-GPC vs Citicoline: Side Effects

Both Alpha-GPC and Citicoline are generally safe and well-tolerated when taken at recommended dosages. Here are the potential side effects of each nootropic:

Alpha-GPC:

May cause mild side effects such as headache, dizziness, and gastrointestinal discomfort in some individuals.
Should be avoided by pregnant or breastfeeding women and those with liver disease.
Limited information is available about the long-term safety of Alpha-GPC.

Citicoline:

May cause mild side effects such as headache, insomnia, and gastrointestinal discomfort in some individuals.
Should be avoided by those with a history of bipolar disorder or low blood pressure.
Long-term use of Citicoline is generally safe, but more research is needed to determine its full safety profile.

In summary, both Alpha-GPC and Citicoline offer a variety of cognitive benefits and have few side effects when taken at recommended dosages. However, Citicoline may offer more neuroprotective and neuroregenerative effects than Alpha-GPC due to its ability to promote cellular repair and protect against cellular damage.

Alpha-GPC vs Choline Bitartrate vs Citicoline: Which is Best?

Alpha-GPC, Choline Bitartrate, and Citicoline are three of the most popular forms of choline supplements, each with unique benefits and drawbacks. Alpha-GPC and Choline Bitartrate are both commonly used as dietary supplements and nootropic compounds due to their potential benefits in boosting cognitive function, especially memory and mental performance. Citicoline, on the other hand, is regarded as the best cholinergic supplement and has been shown to have the most nootropic effects on the cellular level.

While Alpha-GPC and Choline Bitartrate are more affordable and widely available forms of choline supplements, they have several adverse effects and limited scientific studies supporting their efficacy. Citicoline, on the other hand, has been extensively researched and has a more substantial body of scientific evidence demonstrating its potential benefits for improving brain function.

As a source of choline, Citicoline has been shown to be more effective in boosting the synthesis of acetylcholine, the neurotransmitter responsible for memory formation, and spatial memory. It has also been linked to better mental performance and energy levels, making it an attractive option for individuals with brain fog or cognitive decline. Additionally, Citicoline has demonstrated promising neuroprotective effects in neurodegenerative diseases, ischemic stroke, and other cerebrovascular diseases, potentially due to its role in promoting the production of neurotrophic factors.

Overall, Citicoline stands out as the best choice among these three forms of choline supplements due to its superior effectiveness, cellular level, and potential benefits. However, individuals should always consult a healthcare professional before taking any form of choline supplement or nootropic compounds, particularly if they have any underlying medical conditions or are taking medications.

Where To Buy Alpha GPC and CDP Choline (Citicoline)

Both Alpha GPC and CDP Choline (Citicoline) are widely available as dietary supplements. They can be found in many health food stores, as well as online retailers. When buying these supplements, it is important to choose a reputable brand that uses high-quality ingredients.

And right now, Nooceptin is the best citicoline supplement on the market if your goal is cognitive enhancement in a deep, meaningful way.

Nooceptin is a nootropic supplement that contains Citicoline, as well as a blend of other natural compounds that have been shown to improve cognitive function. It is considered to be one of the best citicoline supplements on the market due to its high-quality ingredients and potent formula.

Benefits of Taking Nooceptin:

Boosts cognitive function and mental clarity
Enhances memory function, especially spatial memory
Increases mental energy and focus
Improves brain cell membrane formation
Protects brain cells from oxidative stress
Promotes the synthesis of the neurotransmitter Acetylcholine
Supports neurorepair in ischemic stroke

In conclusion, Nooceptin is the best choice for those looking to enhance their cognitive function and promote long-term brain health. Its potent formula, which includes Citicoline, makes it an effective nootropic supplement for boosting focus, memory, and learning, while also providing neuroprotective benefits.

FAQs

Are vegans choline deficient?

While it's possible for vegans to get enough choline from dietary sources such as soy products, beans, and nuts, it can be difficult to meet the recommended intake of 425-550mg per day. Vegan choline supplements are available and can help ensure adequate intake.

Which form of choline is best absorbed?

Studies have shown that Alpha-GPC and Citicoline (CDP-Choline) are both highly effective at increasing choline levels in the brain due to their high bioavailability and ability to cross the blood-brain barrier.

Can you take alpha gpc and citicoline together?

While it is possible to take both Alpha-GPC and Citicoline together, it is generally not necessary as they both provide similar benefits as cholinergics. It is always recommended to speak with a healthcare professional before taking any new supplements or combining supplements.