How do nootropics affect brain chemistry and neurotransmitters?

Whether you're using natural nootropics or synthetic smart drugs, the appeal of cognitive enhancers is immense. Taking substances that can improve cognitive function, memory, creativity, or motivation can make the difference between getting a promotion and getting fired; aceing an exam or flunking; gaming like a pro or washing out of lobby after lobby.

Understanding how nootropics affect brain chemistry and neurotransmitters is essential to harnessing their full potential and ensuring their safe use. In this article, we'll explore the various ways nootropics influence neurotransmitters, neurotrophic factors, phospholipids, brain energy metabolism, and brain blood flow.

Nootropics and Neurotransmitters


Acetylcholine is a neurotransmitter that plays a critical role in cognitive function, particularly in learning and memory. Some nootropics work by affecting acetylcholine levels in the brain. Choline supplements like Alpha-GPC and Citicoline provide precursors for acetylcholine synthesis, leading to increased acetylcholine levels and improved cognitive function. In one study, Citicoline was found to improve verbal memory in healthy volunteers (Spiers et al., 1996). Additionally, Huperzine A, an acetylcholinesterase inhibitor, prevents the breakdown of acetylcholine, further enhancing acetylcholine levels and cognitive performance (Zhang et al., 2008).


Dopamine is a neurotransmitter involved in motivation, reward, and attention. Certain nootropics can modulate dopamine levels, leading to improved mood, motivation, and cognitive function. For instance, L-tyrosine, a precursor to dopamine, has been shown to boost cognitive performance under stress, possibly due to enhanced dopamine levels (Deijen et al., 1999). Mucuna pruriens, which contains the dopamine precursor L-DOPA, can also increase dopamine levels and may improve cognitive function (Katzenschlager et al., 2004).


Serotonin is a neurotransmitter that plays a significant role in mood regulation, sleep, and appetite. Some nootropics, such as 5-HTP (a precursor to serotonin), can increase serotonin levels, leading to mood enhancement and improved sleep quality (Birdsall, 1998). Rhodiola rosea, an adaptogenic herb, has been shown to modulate serotonin levels, thereby improving mood and reducing stress (Panossian et al., 2007). It must be noted that any nootropic that interacts with serotonin may potentially interact with antidepressant medications that work by inhibiting serotonin reuptake.

Nootropics and Neurotrophic Factors

Brain-Derived Neurotrophic Factor (BDNF)

BDNF is a neurotrophic factor that supports the growth, survival, and differentiation of neurons. It plays a vital role in learning, memory, and synaptic plasticity. Some nootropics, such as Lion's Mane mushroom, can increase BDNF levels, promoting neuronal growth and cognitive function (Lai et al., 2013). Bacopa monnieri, a traditional Ayurvedic herb, has also been shown to elevate BDNF levels, potentially improving memory and cognitive function (Kumar et al., 2016).

Nootropics and Phospholipids

Phospholipids are essential components of cell membranes and play a crucial role in neuronal function. Some nootropics, such as Citicoline, can increase the production of phospholipids, thus enhancing neuronal integrity and function. In a study on healthy adults, Citicoline supplementation was found to improve cognitive performance, possibly due to increased phospholipid synthesis (McGlade et al., 2012).

Nootropics and Brain Energy Metabolism

Brain energy metabolism is vital for optimal cognitive function. Some nootropics, such as creatine, can enhance brain energy metabolism by increasing the availability of adenosine triphosphate (ATP), the primary source of cellular energy. A study on vegetarians, who typically have lower creatine levels, found that creatine supplementation improved cognitive performance (Rae et al., 2003).

Nootropics and Brain Blood Flow

Cerebral blood flow is essential for delivering oxygen and nutrients to the brain, as well as removing metabolic waste products. Some nootropics, like Ginkgo biloba, can increase brain blood flow, leading to improved cognitive function (Kennedy et al., 2000). Vinpocetine, a synthetic derivative of the periwinkle plant, has also been shown to enhance cerebral blood flow and improve cognitive performance in patients with cognitive impairment (Szatmari et al., 2003).

Nootropics and Neuroinflammation

Neuroinflammation can negatively impact cognitive function and contribute to the development of neurodegenerative diseases. Some nootropics, like curcumin, the primary bioactive compound in turmeric, have potent anti-inflammatory properties and may protect against neuroinflammation (Cole et al., 2007). Another example is resveratrol, a polyphenolic compound found in red wine and grapes, which has been shown to exhibit anti-inflammatory effects and potentially improve memory (Witte et al., 2014).

Nootropics and Oxidative Stress

Oxidative stress can lead to neuronal damage and is associated with cognitive decline and neurodegenerative diseases. Some nootropics, such as N-acetyl cysteine (NAC), can counteract oxidative stress by increasing the production of the antioxidant glutathione (Samuni et al., 2013). Green tea extract, which contains the antioxidant epigallocatechin gallate (EGCG), has also been shown to protect against oxidative stress and improve cognitive function (Mereles et al., 2010).

Nootropics and Neuroplasticity

Neuroplasticity is the brain's ability to change and adapt in response to new experiences and learning. Some nootropics, like Noopept, can enhance neuroplasticity, leading to improved learning and memory (Ostrovskaya et al., 2008). Aniracetam, a member of the racetam family of nootropics, has also been found to promote neuroplasticity and improve cognitive function (Wezenberg et al., 2007). The main way that nootropics promote neuroplasticity is by boosting the production or potentiating the action of neurotrophic factors (such as BDNF and NGF) in the brain. Nootropics that boost BDNF include Panax Ginseng, Bacopa monnieri, and synthetic nootropics like Noopept.


Nootropics can impact brain chemistry and neurotransmitters in various ways, leading to a range of cognitive benefits. By modulating neurotransmitter levels, enhancing neurotrophic factors, improving phospholipid synthesis, supporting brain energy metabolism, increasing brain blood flow, reducing neuroinflammation and oxidative stress, and promoting neuroplasticity, nootropics can optimize cognitive function and overall brain health.

As always, it is essential to consult with a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

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